Betaxolol ophthalmic and Marcaine Preservative Free
Determining the interaction of Betaxolol ophthalmic and Marcaine Preservative Free and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using bupivacaine together with betaxolol ophthalmic may increase the effects of bupivacaine. Contact your doctor if you experience drowsiness, mental status changes, convulsions, irregular heart beat or any other heart abnormalities, and low blood pressure. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Beta-blockers may increase the risk of bupivacaine-induced side effects. The proposed mechanism is increased bupivacaine levels due to hepatic enzyme inhibition (propranolol) and/or additive negative inotropic effects on the heart. Patients with heart failure may be at a greater risk. Data have been conflicting and variable. Theoretically, beta-blocker ophthalmic solutions may also interact, as they are systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels.
MANAGEMENT: Caution is recommended if multiple doses of bupivacaine are administered in the presence of a beta-blocker. Monitoring for drowsiness, mental status changes, convulsions, ECG changes, and hypotension is advisable during concurrent therapy.
- Ponten J, Biber B, Bjuro T, Henriksson BA, Hjalmarson A, Lundberg D "Beta-receptor blockade and spinal anaesthesia. Withdrawal versus continuation of long-term therapy." Acta Anaesthesiol Scand Suppl 76 (1982): 62-9
- Roitman K, Sprung J, Wallace M, Matjasko J "Enhancement of bupivacaine cardiotoxcity with cardiac glycosides and beta-adrenergic blockers: a case report." Anesth Analg 76 (1993): 658-61
- Ponten J, Biber B, Henriksson BA, Jonsteg C "Bupivacaine for intercostal nerve blockade in patients on long-term beta-receptor blocking therapy." Acta Anaesthesiol Scand Suppl 76 (1982): 70-7
Generic Name: betaxolol ophthalmic
Brand name: Betoptic S, Betoptic
Synonyms: Betaxolol (Ophthalmic)
Generic Name: bupivacaine
Brand name: Bupivacaine Fisiopharma, Bupivacaine Spinal, Marcaine, Marcaine Preservative Free, Marcaine Spinal, P-Care M, ReadySharp Bupivacaine, Sensorcaine, Sensorcaine-MPF, Sensorcaine-MPF Spinal, Marcaine HCl
Synonyms: Marcaine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Betaxolol ophthalmic-Marcaine Spinal
- Betaxolol ophthalmic-Marcaine/Epinephrine
- Betaxolol ophthalmic-Marcaine/Epinephrine PF
- Betaxolol ophthalmic-Mardrops-EX
- Betaxolol ophthalmic-Margesic
- Betaxolol ophthalmic-Margesic Oral
- Marcaine Preservative Free-Betaxolol Tablets
- Marcaine Preservative Free-Bethanechol
- Marcaine Preservative Free-Bethanechol Chloride
- Marcaine Preservative Free-Bethanechol Oral, Subcutaneous
- Marcaine Preservative Free-Bethkis
- Marcaine Preservative Free-Bethkis inhalation