Bethkis and Daptomycin Intravenous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration of daptomycin and tobramycin may alter the plasma concentrations of both drugs. The mechanism of interaction is unknown. In six healthy adult volunteers given a single 2 mg/kg IV dose of daptomycin and a 1 mg/kg IV dose of tobramycin, the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of daptomycin increased by 12.7% and 8.7%, respectively, compared to administration of the drug alone. Tobramycin Cmax and AUC decreased by 10.7% and 6.6%, respectively, during coadministration with daptomycin relative to administration alone. These differences were not statistically significant. However, the interaction between tobramycin and a clinical dose of daptomycin (4 mg/kg) has not been studied. Daptomycin package labeling recommends caution during coadministration with tobramycin.

Bethkis

Generic Name: tobramycin

Brand name: Bethkis, Kitabis Pak, Tobi, TOBI Podhaler

Synonyms: Bethkis (inhalation), Bethkis Inhalation Solution

What is Bethkis?

Daptomycin Intravenous

Generic Name: daptomycin

Brand name: Cubicin, Cubicin RF

Synonyms: Daptomycin, DAPTOmycin

What is Daptomycin Intravenous?