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Bexarotene and Lopid

Determining the interaction of Bexarotene and Lopid and the possibility of their joint administration.

Check result:

Bexarotene <> Lopid

Relevance: 21.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using bexarotene together with gemfibrozil is generally not recommended. Combining these medications may significantly increase the blood levels of bexarotene. You may be more likely to experience serious side effects such as elevated cholesterol and triglyceride levels, underactive thyroid (hypothyroidism), liver function abnormalities, low blood cell counts, and inflammation of the pancreas (pancreatitis). Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with gemfibrozil may significantly increase the plasma concentrations of bexarotene. The exact mechanism of interaction is unknown. In an analysis of the pharmacokinetic data acquired during two clinical studies of bexarotene treatment in patients with cutaneous T-cell lymphoma, investigators found that mean plasma bexarotene concentrations (dose-normalized) were more than 5 times higher with concomitant gemfibrozil therapy than without. Plasma metabolite chromatography profiles were consistent with an inhibition of the oxidative metabolism of bexarotene by gemfibrozil, although the exact CYP450 isoenzyme involved has not been elucidated. The combination has also been reported to increase serum triglyceride levels in some patients. By contrast, concomitant fenofibrate did not appear to affect bexarotene pharmacokinetics; however, data were insufficient to provide an adequate assessment.

MANAGEMENT: The use of bexarotene in combination with gemfibrozil should generally be avoided.

References

Talpur R, Ward S, Apisarnthanarax N, Breuer-Mcham J, Duvic M "Optimizing bexarotene therapy for cutaneous T-cell lymphoma." J Am Acad Dermatol 47 (2002): 672-84
Loewen GR, Cato III AE, Timony G, Ulm EH, Crowley CC, Yocum RC "Concomitant gemfibrozil, but not atorvastatin, is associated with increased plasma bexarotene concentrations. Available from: URL: http://www.aapsj.org/abstracts/AM_2000/3256.htm." ([cited 2013]):
"Product Information. Targretin (bexarotene)" Ligand Pharmaceuticals, San Diego, CA.

Bexarotene

Generic Name: bexarotene

Brand name: Targretin

Synonyms: Bexarotene (Systemic)

What is Bexarotene?

Lopid

Generic Name: gemfibrozil

Brand name: Lopid

Synonyms: n.a.

What is Lopid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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