Bexarotene and Nembutal
Determining the interaction of Bexarotene and Nembutal and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of bexarotene. In vitro studies suggest that bexarotene is metabolized by CYP450 3A4. However, concomitant administration with multiple doses of ketoconazole, a potent CYP450 3A4 inhibitor, did not alter bexarotene plasma concentrations, which would imply that bexarotene elimination is not substantially dependent on CYP450 3A4 metabolism in vivo. The effects of concomitant CYP450 3A4 inducers (e.g., carbamazepine, phenytoin, phenobarbital, rifampin) on the pharmacokinetics of bexarotene have not been studied.
- "Product Information. Targretin (bexarotene)" Ligand Pharmaceuticals, San Diego, CA.
Generic Name: bexarotene
Brand name: Targretin
Synonyms: Bexarotene (Systemic)
Generic Name: pentobarbital
Brand name: Nembutal, Nembutal Sodium
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.