Bexarotene Capsules and Dalfopristin and quinupristin
Determining the interaction of Bexarotene Capsules and Dalfopristin and quinupristin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 may theoretically increase the plasma concentrations of bexarotene. In vitro studies suggest that bexarotene is metabolized by CYP450 3A4. However, concomitant administration with multiple doses of ketoconazole, a potent CYP450 3A4 inhibitor, did not alter bexarotene plasma concentrations, which would imply that bexarotene elimination is not substantially dependent on CYP450 3A4 metabolism in vivo. Conversely, bexarotene appears to be an inducer of CYP450 3A4 and may reduce the plasma concentrations of CYP450 3A4 inhibitors that are also substrates of the isoenzyme, such as azole antifungals, macrolides, some calcium channel blockers, mifepristone, and nefazodone. The clinical significance is unknown.
- "Product Information. Targretin (bexarotene)" Ligand Pharmaceuticals, San Diego, CA.
Generic Name: bexarotene
Brand name: Targretin
Synonyms: Bexarotene (Systemic), Bexarotene
Generic Name: dalfopristin / quinupristin
Brand name: Synercid
Synonyms: Quinupristin and Dalfopristin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Bexarotene Capsules-Daliresp
- Bexarotene Capsules-Dallergy
- Bexarotene Capsules-Dallergy (Dexbrompheniramine and Phenylephrine Syrup)
- Bexarotene Capsules-Dallergy (Dexbrompheniramine and Phenylephrine Tablets)
- Bexarotene Capsules-Dallergy Chewable Tablets
- Bexarotene Capsules-Dallergy Drops
- Dalfopristin and quinupristin-Bexarotene Gel
- Dalfopristin and quinupristin-Bexarotene topical
- Dalfopristin and quinupristin-Bexsero
- Dalfopristin and quinupristin-Bextra
- Dalfopristin and quinupristin-Bexxar
- Dalfopristin and quinupristin-Beyaz