Bexarotene Capsules and Dapsone topical
Determining the interaction of Bexarotene Capsules and Dapsone topical and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Theoretically, coadministration of dapsone with inducers of CYP450 3A4 such as rifamycins, anticonvulsants, barbiturates, and St. John's wort may increase the formation of dapsone hydroxylamine, a metabolite associated with hemolysis. Dose-related hemolysis is the most common adverse event associated with oral dapsone in both patients with or without glucose-6-phosphate dehydrogenase (G6PD) deficiency. While clinical studies have not demonstrated evidence of clinically significant anemia in patients treated with dapsone 5% gel for acne vulgaris, an increased reticulocyte count and a decreased hemoglobin level were noted to be associated in a G6PD-deficient patient. Exposure to dapsone from the recommended topical dose is about 1% of that from a 100 mg oral dose.
- "Product Information. Aczone (dapsone topical)." QLT USA, Inc, Fort Collins, CO.
Generic Name: bexarotene
Brand name: Targretin
Synonyms: Bexarotene (Systemic), Bexarotene
Generic Name: dapsone topical
Brand name: Aczone
Synonyms: Dapsone (Topical)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Bexarotene Capsules-Daptacel
- Bexarotene Capsules-Daptomycin
- Bexarotene Capsules-Daptomycin Injection
- Bexarotene Capsules-Daptomycin Intravenous
- Bexarotene Capsules-Daranide
- Bexarotene Capsules-Daraprim
- Dapsone topical-Bexarotene Gel
- Dapsone topical-Bexarotene topical
- Dapsone topical-Bexsero
- Dapsone topical-Bextra
- Dapsone topical-Bexxar
- Dapsone topical-Beyaz