Bextra and E.E.S. 200 Oral
Determining the interaction of Bextra and E.E.S. 200 Oral and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using valdecoxib together with erythromycin may increase the effects of valdecoxib. Contact your doctor if you experience heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inhibitors of CYP450 2C9 and/or 3A4 may increase the plasma concentrations of valdecoxib, which is metabolized by these isoenzymes. According to the product labeling for valdecoxib, multi-dose administration of fluconazole (CYP450 2C9/3A4 inhibitor) and ketoconazole (CYP450 3A4 inhibitor) increased the area under the plasma concentration-time curve (AUC) of a single 20 mg dose of valdecoxib by 62% and 38%, respectively. Parecoxib, a prodrug of valdecoxib, may be similarly affected.
MANAGEMENT: The possibility of prolonged and/or increased pharmacologic effects of valdecoxib or parecoxib, including serious adverse effects such as gastrointestinal ulceration and bleeding, should be considered during concomitant therapy with CYP450 2C9 or 3A4 inhibitors, particularly combination (2C9/3A4) inhibitors such as fluconazole, fluvoxamine, imatinib, and zafirlukast. Dose reductions of the COX-2 inhibitor may be required.
- "Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.
Generic Name: erythromycin
Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV
Synonyms: Erythromycin, Erythromycin (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Bextra-E.E.S. 400 Oral
- Bextra-E.E.S. Granules Oral
- Bextra-E.S.P.
- Bextra-Easprin
- Bextra-EC-Naprosyn
- Bextra-Echinacea
- E.E.S. 200 Oral-Bexxar
- E.E.S. 200 Oral-Beyaz
- E.E.S. 200 Oral-BeyondClear
- E.E.S. 200 Oral-Bi-Zets/Benzo-Troches
- E.E.S. 200 Oral-Biaxin
- E.E.S. 200 Oral-Biaxin (Clarithromycin Oral Suspension)