Bextra and Gildess 24 Fe

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ethinyl estradiol together with valdecoxib may increase the effects of ethinyl estradiol. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with valdecoxib may increase the plasma concentrations of ethinylestradiol and norethisterone. The mechanism of interaction has not been described, although valdecoxib has been shown to be a weak inhibitor of CYP450 3A4, an isoenzyme of which ethinylestradiol and norethisterone are substrates. According to product labeling, coadministration of valdecoxib (40 mg twice a day) and norethisterone-ethinylestradiol (1 mg-35 mcg oral contraceptive combination) resulted in a 20% and 34% increase, respectively, in the systemic exposure (AUC) of the hormones. The clinical significance of these changes in terms of safety is unknown. However, an increase in ethinylestradiol exposure can increase the incidence of adverse reactions associated with oral contraceptives such as venous thromboembolic complications and certain cancers.

MANAGEMENT: The potential increase in ethinylestradiol concentration should be considered when selecting an oral contraceptive for use with valdecoxib.

Bextra

Generic Name: valdecoxib

Brand name:

Synonyms: n.a.

What is Bextra?

Gildess 24 Fe

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Estrostep Fe, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Taytulla, Tilia Fe, Tri-Legest Fe, Blisovi 24 Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Tri-Norinyl, Zenchent, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: n.a.

What is Gildess 24 Fe?