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Bextra and Sudafed PE Pressure+Pain+Cold

Determining the interaction of Bextra and Sudafed PE Pressure+Pain+Cold and the possibility of their joint administration.

Check result:

Bextra <> Sudafed PE Pressure+Pain+Cold

Relevance: 10.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

According to the manufacturer, the coadministration with valdecoxib 40 mg twice a day for 7 days has been shown to significantly increase the plasma concentrations of dextromethorphan. The proposed mechanism is decreased clearance of dextromethorphan due to inhibition of the CYP450 2D6 enzymatic pathway by valdecoxib at high dosages. However, the dextromethorphan levels reported were still almost 5-fold lower than those observed in CYP450 2D6 poor metabolizers. No particular intervention should be necessary when valdecoxib is administered under normal circumstances with dextromethorphan. At unusually high dosages of valdecoxib, there may be a theoretical risk of increased adverse effects of dextromethorphan such as drowsiness, dizziness, excitation, mental confusion, and respiratory depression. Parecoxib, a prodrug of valdecoxib, may also interact.

References

"Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.

Bextra

Generic Name: valdecoxib

Brand name:

Synonyms: n.a.

What is Bextra?

Sudafed PE Pressure+Pain+Cold

Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine

Brand name: Decorel Forte Plus Cold/Cough, Mucinex Fast-Max, Mucinex Fast-Max Cold and Flu, Mucinex Fast-Max Congestion and Cold, Mucinex Fast-Max Severe Cold, Tylenol Cold Multi-Symptom Severe Daytime, Tylenol Cold Head Congestion Severe, Non-Pseudo Cold Relief, Phenflu DM, Sudafed PE Cold & Cough, Cold & Cough PE, Cold Head Congestion Severe Daytime, Cold Multi-Symptom Severe Daytime Cool Ice, Tylenol Cold & Flu Severe, Mucinex Children's Multi-Symptom Cold & Fever, Mucinex Fast-Max Cold, Flu & Sore Throat, Mucinex Fast-Max Severe Congestion & Cold, Cough & Sore Throat, DayQuil Severe Cold & Flu, Adult Cold, Cold & Flu Severe, Mucinex Sinus-Max Severe Congestion Relief, Delsym Cough + Cold Daytime, Severe Day Time Cold & Flu, Mucinex Fast-Max Cold & Flu, Mucinex Sinus-Max Pressure, Pain & Cough

Synonyms: n.a.

What is Sudafed PE Pressure+Pain+Cold?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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