Bextra and Tegretol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using carBAMazepine together with valdecoxib may decrease the effects of valdecoxib. Contact your doctor if your condition changes or if you experience loss of pain control. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with phenytoin and/or other enzyme-inducing anticonvulsants may decrease the plasma concentrations of valdecoxib. The mechanism is induction of CYP450 2C9 and 3A4, the isoenzymes responsible for the metabolic clearance of valdecoxib. According to product labeling, coadministration of phenytoin (300 mg once daily) and valdecoxib (40 mg twice a day) for 12 days resulted in decreased steady-state systemic exposure (AUC) of valdecoxib by 27% compared to administration of valdecoxib alone. The pharmacokinetics of phenytoin was not significantly affected in the presence of valdecoxib. No data are available for other anticonvulsants.

MANAGEMENT: Patients already stabilized on valdecoxib may experience loss of pain and inflammation control with the coadministration of phenytoin and/or other enzyme-inducing anticonvulsants such as carbamazepine, oxcarbazepine, phenobarbital, and primidone. Pharmacologic response to valdecoxib should be monitored more closely whenever these agents are added to or withdrawn from therapy, and the valdecoxib dosage adjusted as necessary. In addition, because valdecoxib is a moderate inhibitor of CYP450 2C9 and 2C19 and a weak inhibitor of 2D6 and 3A4, valdecoxib labeling recommends that routine monitoring for alteration of antiepileptic efficacy be performed when therapy with valdecoxib is either initiated or discontinued in patients receiving anticonvulsants.

Bextra

Generic Name: valdecoxib

Brand name:

Synonyms: n.a.

What is Bextra?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?