Biaxin (Clarithromycin Oral Suspension) and Dolutegravir Sodium and Rilpivirine Hydrochloride
Determining the interaction of Biaxin (Clarithromycin Oral Suspension) and Dolutegravir Sodium and Rilpivirine Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using rilpivirine together with clarithromycin. Combining these medications may increase the blood levels and effects of rilpivirine. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with macrolide antibiotics that are inhibitors of CYP450 3A4 may increase the blood concentrations of rilpivirine, which is primarily metabolized by the isoenzyme.
MANAGEMENT: Caution is advised if rilpivirine is used with macrolide antibiotics that are inhibitors of CYP450 3A4. Alternative antibiotics that do not interfere with rilpivirine metabolism, such as azithromycin, should be considered whenever possible.
- "Product Information. Edurant (rilpivirine)." Tibotec Pharmaceuticals, Titusville, NJ.
Generic Name: clarithromycin
Brand name: Biaxin, Biaxin XL
Synonyms: Biaxin (Oral Suspension), Biaxin
Generic Name: dolutegravir / rilpivirine
Brand name: Juluca
Synonyms: Dolutegravir and rilpivirine, Dolutegravir and Rilpivirine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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