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Biaxin Filmtab and Fosamprenavir

Determining the interaction of Biaxin Filmtab and Fosamprenavir and the possibility of their joint administration.

Check result:

Biaxin Filmtab <> Fosamprenavir

Relevance: 22.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Drugs that act as both substrate and inhibitor of the CYP450 3A4 isoenzyme may alter the plasma concentration of amprenavir. Amprenavir may increase blood levels of the CYP450 3A4 inhibitor. The extent of the alterations in serum drug levels is unknown and the clinical significance is uncertain. When concomitant therapy is required, the patient should be monitored for adverse effects of both drugs and dose adjustments made when indicated.

References

Falloon J, Piscitelli S, Vogel S, Sadler B, Mitsuya H, Kavlick MF, Yoshimura K, Rogers M, LaFon S, Manion DJ, Lane HC, Masur "Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: Pharmacokinetic drug interactions and antiviral activity." Clin Infect Dis 30 (2000): 313-8
Polk RE, Crouch MA, Israel DS, et al. "Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men." Pharmacotherapy 19 (1999): 1378-84
"Product Information. Agenerase (amprenavir)." Glaxo Wellcome, Research Triangle Pk, NC.

Biaxin Filmtab

Generic Name: clarithromycin

Brand name: Biaxin, Biaxin XL

Synonyms: Biaxin (Oral Suspension), Biaxin

What is Biaxin Filmtab?

Fosamprenavir

Generic Name: fosamprenavir

Brand name: Lexiva, Telzir

Synonyms: n.a.

What is Fosamprenavir?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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