Biaxin Filmtab and Indinavir Sulfate
Determining the interaction of Biaxin Filmtab and Indinavir Sulfate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration of indinavir (800 mg every eight hours) and clarithromycin (500 mg every 12 hours) for one week increased the area under the plasma concentration-time curve (AUC) of indinavir by 29%. The AUC of clarithromycin increased 53%. The mechanism of this interaction is related to inhibition of CYP450 3A4 hepatic metabolism. The patient should be monitored for drug-related toxicities and be advised to report symptoms such as nausea, vomiting, diarrhea, flank or back pain, or hematuria. Dose reductions may be necessary if evidence of an interaction is observed. Azithromycin and dirithromycin are not expected to interact and may be considered as alternatives.
- Boruchoff SE, Sturgill MG, Grasing KW, et al. "The steady-state disposition of indinavir is not altered by the concomitant administration of clarithromycin." Clin Pharmacol Ther 67 (2000): 351-9
- "Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.
Generic Name: clarithromycin
Brand name: Biaxin, Biaxin XL
Synonyms: Biaxin (Oral Suspension), Biaxin
Generic Name: indinavir
Brand name: Crixivan
Synonyms: Indinavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Biaxin Filmtab-Indiomin MB
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- Biaxin Filmtab-Indium DTPA
- Biaxin Filmtab-Indium In-111 Pentetreotide
- Biaxin Filmtab-Indium Oxyquinoline
- Biaxin Filmtab-Indocid
- Indinavir Sulfate-Biaxin XL
- Indinavir Sulfate-Bicalutamide
- Indinavir Sulfate-Bicarsim
- Indinavir Sulfate-Bicarsim Forte
- Indinavir Sulfate-Bicillin C-R
- Indinavir Sulfate-Bicillin C-R 900/300