Drug search by name

Biaxin Filmtab and Pradaxa

Determining the interaction of Biaxin Filmtab and Pradaxa and the possibility of their joint administration.

Check result:

Biaxin Filmtab <> Pradaxa

Relevance: 22.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with clarithromycin may slightly increase the bioavailability of dabigatran following oral administration of dabigatran etexilate. The proposed mechanism is clarithromycin inhibition of the P-glycoprotein efflux transporter, of which dabigatran etexilate is a substrate. When dabigatran etexilate was coadministered with clarithromycin 500 mg twice a day in healthy volunteers, increases in dabigatran peak plasma concentration (Cmax) by about 15% and systemic exposure (AUC) by about 19% were observed without any clinical safety concern. Dabigatran had no significant effect on the pharmacokinetics of clarithromycin. No dosage adjustment for dabigatran etexilate is recommended during coadministration with clarithromycin, but caution may be advisable.

References

"Product Information. Pradaxa (dabigatran)." Boehringer-Ingelheim, Ridgefield, CT.
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Pradax (dabigatran)." Boehringer Ingelheim (Canada) Ltd, Burlington, IA.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Biaxin Filmtab

Generic Name: clarithromycin

Brand name: Biaxin, Biaxin XL

Synonyms: Biaxin (Oral Suspension), Biaxin

What is Biaxin Filmtab?

Pradaxa

Generic Name: dabigatran

Brand name: Pradaxa

Synonyms: n.a.

What is Pradaxa?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions