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Biaxin XL and Zidovudine Capsules and Tablets

Determining the interaction of Biaxin XL and Zidovudine Capsules and Tablets and the possibility of their joint administration.

Check result:

Biaxin XL <> Zidovudine Capsules and Tablets

Relevance: 12.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Clarithromycin may alter the rate at which zidovudine is absorbed. Conflicting reports indicate that peak serum zidovudine concentrations may increase or decrease. The proposed mechanism is a change in gastric emptying time induced by clarithromycin. It is recommended that these two agents be administered at least 2 hours apart.

References

Gustavson LE, Chu SY, Mackenthun A, Gupta MS, Craft JC "Drug interaction between clarithromycin and oral zidovudine in HIV-1 infected patients." Clin Pharmacol Ther 53 (1993): 163
Vance E, Watsonbitar M, Gustavson L, Kazanjian P "Pharmacokinetics of clarithromycin and zidovudine in patients with AIDS." Antimicrob Agents Chemother 39 (1995): 1355-60

Biaxin XL

Generic Name: clarithromycin

Brand name: Biaxin XL, Biaxin

Synonyms: n.a.

What is Biaxin XL?

Zidovudine Capsules and Tablets

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Zidovudine (oral/injection), Zidovudine

What is Zidovudine Capsules and Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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