Bicalutamide and Coumadin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

In vitro studies have shown that bicalutamide can displace coumarin anticoagulants such as warfarin from protein-binding sites, theoretically resulting in enhanced anticoagulant effects. PT should be monitored closely when bicalutamide is initiated in patients already receiving coumarin anticoagulants. The anticoagulant dosage should be adjusted as needed. Patients should be advised to notify their physicians if they experience any signs of excessive anticoagulation, such as unusual or prolonged bleeding, bruising, vomiting, change in stool or urine color, headache, dizziness, or weakness.

Bicalutamide

Generic Name: bicalutamide

Brand name: Casodex

Synonyms: n.a.

What is Bicalutamide?

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?