BiCNU and Neosar
Determining the interaction of BiCNU and Neosar and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using carmustine together with cyclophosphamide may increase the effects of carmustine. Contact your doctor if you experience extreme fatigue, unusual easy bruising or bleeding; black, bloody or tarry stools, fever, chills, sore throat, and lung or breathing problems. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited animal data and limited observations of humans suggest that cyclophosphamide and/or cisplatin may increase plasma carmustine (BCNU) levels. It is suspected that cisplatin can decrease the metabolism of BCNU. Blood BCNU levels are positively correlated with a steroid-responsive pulmonary injury seen in patients treated with BCNU, and pretreatment or concomitant therapy with cyclophosphamide and/or cisplatin may increase the risk.
MANAGEMENT: Close monitoring for signs of pulmonary toxicity is recommended during treatment.
- Fassas A, Gojo I, Rapoport A, et al. "Pulmonary toxicity syndrome following CDEP (cyclophosphamide, dexamethasone, etoposide, cisplatin) chemotherapy." Bone Marrow Transplant 28 (2001): 399-403
- Jones RB, Matthes S, Dufton C, et al "Pharmacokinetic/pharmacodynamic interactions of intensive cyclophosphamide, cisplatin, and BCNU in patients with breast cancer." Breast Cancer Res Treat 26 (1993): S11-7
Generic Name: cyclophosphamide
Brand name: Cytoxan, Neosar, Cytoxan Lyophilized
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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