Bictegravir Sodium, Emtricitabine, and Tenofovir Alafenamide Fumarate and Trimipramine Maleate

• Generic Name: bictegravir / emtricitabine / tenofovir alafenamide
• Dosage Forms: n.a.
• Other Brand Names: Biktarvy

Treatment of HIV-1 infection in antiretroviral-naive (have not previously received antiretroviral therapy) or antiretroviral-experienced (previously treated) adults.

Fixed combination of BIC/FTC/TAF used alone as a complete regimen for treatment of HIV-1 infection; concomitant use with other antiretrovirals not recommended.

For initial treatment in antiretroviral-naive adults, experts state BIC/FTC/TAF is a recommended INSTI-based regimen for most adults.

For antiretroviral-experienced adults, manufacturer states BIC/FTC/TAF can be used to replace the current antiretroviral regimen in those with plasma HIV-1 RNA levels <50 copies/mL on a stable antiretroviral regimen for ≥3 months who have no history of treatment failure and are infected with HIV-1 with no known substitutions associated with resistance to the antiretroviral components of the fixed combination (i.e., bictegravir, emtricitabine, tenofovir).

• Generic Name: trimipramine
• Dosage Forms: n.a.
• Other Brand Names: Surmontil

Management of major depressive disorder.

Although has been used in the treatment of insomnia and other sleep disturbances in depressed patients, tricyclics generally are less effective for insomnia and associated with more serious adverse reactions than conventional hypnotics.

Has been used in the treatment of nocturnal enuresis (bedwetting) in pediatric patients; however, clinical efficacy not established in controlled trials.