Biktarvy and Guanfacine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Bictegravir may increase the blood levels and effects of guanFACINE. You may need a dose adjustment if you have been receiving guanFACINE and are starting treatment with bictegravir. Likewise, if you have been receiving both medications, the dose of guanFACINE may need to be adjusted if bictegravir is discontinued. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with bictegravir may increase the plasma concentrations of drugs that are substrates of organic cation transporter 2 (OCT2) and multidrug and toxin extrusion transporter 1 (MATE1). The mechanism is inhibition of OCT2- and MATE1-mediated renal tubular secretion by bictegravir. In healthy volunteers, coadministration of metformin 500 mg twice daily with bictegravir/tenofovir alafenamide 50 mg/25 mg once daily increased mean metformin peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) by 28%, 39% and 36%, respectively, compared to administration of metformin alone.

MANAGEMENT: Caution is advised when bictegravir is used with drugs that are substrates of OCT2 or MATE1, particularly those with a narrow therapeutic range. Close monitoring is particularly recommended in patients with moderate renal impairment (CrCl 30 to 59 mL/min) who are to be administered bictegravir and metformin, due to the increased risk of lactic acidosis. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever bictegravir is added to or withdrawn from therapy.

Biktarvy

Generic Name: bictegravir / emtricitabine / tenofovir alafenamide

Brand name: Biktarvy

Synonyms: n.a.

What is Biktarvy?

Guanfacine

Generic Name: guanfacine

Brand name: Intuniv, Tenex

Synonyms: GuanFACINE

What is Guanfacine?