Bio-Cef and Metaglip

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cephalexin together with metFORMIN may increase the effects of metFORMIN on lowering blood sugar. This could cause your blood sugar levels to get too low. Talk with your doctor before using cephalexin together with metFORMIN. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concomitant administration of cephalexin may increase plasma concentrations and adverse effects of metformin. The mechanism is competitive inhibition of active renal tubular secretion. After administration of single doses of 500 mg cephalexin and metformin, the mean maximum plasma concentration (Cmax) of metformin increased by 34%, area under the concentration-time curve (AUC) increased by 24%, and metformin renal clearance decreased by 14%. Adverse effects were not reported in this study.

MANAGEMENT: Patients receiving this combination should be monitored for altered efficacy and safety of metformin. Metformin dose adjustments may be required.

Bio-Cef

Generic Name: cephalexin

Brand name: Daxbia, Keflex, Panixine DisperDose

Synonyms: Bio-Cef (Oral)

What is Bio-Cef?

Metaglip

Generic Name: glipizide / metformin

Brand name: Metaglip

Synonyms: n.a.

What is Metaglip?