Bismuth Subcitrate, Metronidazole, and Tetracycline and Celexib 100- EZS
Determining the interaction of Bismuth Subcitrate, Metronidazole, and Tetracycline and Celexib 100- EZS and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using metroNIDAZOLE together with celecoxib can increase the effects of celecoxib. This can cause abdominal pain, tarry stools, nausea, vomiting, lethargy or drowsiness. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inhibitors of CYP450 2C9 may increase the plasma concentrations of celecoxib, which is primarily metabolized by the isoenzyme. The possibility of prolonged and/or increased pharmacologic effects of celecoxib should be considered.
MANAGEMENT: Clinical monitoring for altered effects of celecoxib is recommended following initiation or discontinuation of a CYP450 2C9 inhibitor. Dosage adjustments may be required if an interaction is suspected. Patients should be advised to notify their physician if they experience potential signs and symptoms of celecoxib toxicity such as abdominal pain, black or tarry stools, nausea, vomiting, lethargy, fluid retention, swelling of legs, and worsening heart failure.
- "Product Information. Celebrex (celecoxib)." Searle, Chicago, IL.
Generic Name: bismuth subcitrate potassium / metronidazole / tetracycline
Brand name: Pylera
Synonyms: Bismuth subcitrate potassium, metronidazole, and tetracycline
Generic Name: celecoxib
Brand name: Celebrex, Celebrex
Synonyms: Celecoxib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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