Drug search by name

Bismuth subsalicylate, metronidazole, and tetracycline and Seconal Sodium

Determining the interaction of Bismuth subsalicylate, metronidazole, and tetracycline and Seconal Sodium and the possibility of their joint administration.

Check result:

Bismuth subsalicylate, metronidazole, and tetracycline <> Seconal Sodium

Relevance: 08.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking metroNIDAZOLE, tell your doctor if you also use secobarbital. This combination may decrease the effects of metroNIDAZOLE. You may need dose adjustments or special tests in order to safely take both medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

ADJUST DOSE: Coadministration with a barbiturate may significantly decrease the plasma concentrations and pharmacologic effects of nitroimidazoles. The proposed mechanism is barbiturate induction of nitroimidazole metabolism via hepatic microsomal enzymes. The interaction has been reported with metronidazole and has been attributed to treatment failure in patients with trichomoniasis, giardiasis, or amebiasis given the normally recommended dosages of metronidazole while being treated concomitantly with phenobarbital. Significantly increased clearance and shortened half-life of metronidazole were demonstrated. In many cases, metronidazole dosage had to be doubled or even tripled to achieve a cure. No data are available for tinidazole.

MANAGEMENT: Patients treated concomitantly with a barbiturate may require a higher dosage of metronidazole to achieve a cure. Two- to threefold dosage increases are not uncommon. Pharmacologic response to metronidazole should be monitored and the dosage adjusted as necessary. Given its structural similarities to metronidazole, the same precaution may be applicable during therapy with tinidazole, although clinical data are lacking.

References

"Product Information. Flagyl (metronidazole)." Searle, Skokie, IL.
"Product Information. Tindamax (tinidazole)." Presutti Laboratories Inc, Arlington Heights, IL.
Loft S, Sonne J, Poulsen HE, Peterson KT, Jorgensen BG, Dossing M "Inhibition and induction of metronidazole and antipyrine metabolism." Eur J Clin Pharmacol 32 (1987): 35-41
Mead PB, Gibson M, Schentag JJ, Ziemniak JA "Possible alteration of metronidazole metabolism by phenobarbital." N Engl J Med 306 (1982): 1490
Gupte S "Phenobarbital and metabolism of metronidazole." N Engl J Med 308 (1983): 529

Bismuth subsalicylate, metronidazole, and tetracycline

Generic Name: bismuth subsalicylate / metronidazole / tetracycline

Brand name:

Synonyms: Bismuth subsalicylate, metronidazole, and tetracycline (Oral)

What is Bismuth subsalicylate, metronidazole, and tetracycline?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions