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Bivalirudin and Fedratinib Hydrochloride

Determining the interaction of Bivalirudin and Fedratinib Hydrochloride and the possibility of their joint administration.

Check result:
Bivalirudin <> Fedratinib Hydrochloride
Relevance: 16.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.MONITOR: Concomitant use of thrombin inhibitors and antiplatelet agents may increase the risk of bleeding complications due to additive or synergistic effects on the clotting cascade. MANAGEMENT: Coadministration of thrombin inhibitors and antiplatelet agents should be undertaken with caution and only after thorough assessment of risks and benefits. Close clinical and laboratory observation for bleeding complications is recommended. References "Product Information. Angiomax (bivalirudin)" The Medicines Compny, Cambridge, MA. "Product Information. Acova (argatroban)" SmithKline Beecham, Philadelphia, PA. "Product Information. Refludan (lepirudin)." Hoechst Marion-Roussel Inc, Kansas City, MO.

Professional:

MONITOR: Concomitant use of thrombin inhibitors and antiplatelet agents may increase the risk of bleeding complications due to additive or synergistic effects on the clotting cascade.

MANAGEMENT: Coadministration of thrombin inhibitors and antiplatelet agents should be undertaken with caution and only after thorough assessment of risks and benefits. Close clinical and laboratory observation for bleeding complications is recommended.

References
  • "Product Information. Angiomax (bivalirudin)" The Medicines Compny, Cambridge, MA.
  • "Product Information. Acova (argatroban)" SmithKline Beecham, Philadelphia, PA.
  • "Product Information. Refludan (lepirudin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Bivalirudin

Generic Name: bivalirudin

Brand name: Angiomax

Synonyms: n.a.

Fedratinib Hydrochloride

Generic Name: fedratinib

Brand name: Inrebic

Synonyms: Fedratinib

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle