Bivalirudin and Kinlytic

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using urokinase together with bivalirudin can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: The concomitant administration of thrombin inhibitors and thrombolytic agents may increase the risk of bleeding complications. Intracranial bleeding has been reported in patients with acute myocardial infarction treated with argatroban or lepirudin and thrombolytic therapy (recombinant tPA or streptokinase). The mechanism may be attributable to complementary or synergistic effects of these agents on thrombin-dependent functions and activated partial thromboplastin time (aPPT).

MANAGEMENT: Coadministration should be undertaken with caution and only after thorough assessment of risks and benefits. Close clinical and laboratory observation for bleeding complications is recommended.

Bivalirudin

Generic Name: bivalirudin

Brand name: Angiomax

Synonyms: n.a.

What is Bivalirudin?

Kinlytic

Generic Name: urokinase

Brand name: Kinlytic, Abbokinase, Abbokinase Open-Cath

Synonyms: n.a.

What is Kinlytic?