Bivalirudin Intravenous and Coumadin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using warfarin together with bivalirudin. This can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: The concomitant administration of bivalirudin and other anticoagulants may increase the risk of bleeding complications due to additive or synergistic effects on the clotting cascade. In clinical trials, the use of bivalirudin with heparin or warfarin in patients undergoing PTCA was associated with increased risks of major bleeding events. According to the manufacturer, results from drug interaction studies do not suggest pharmacodynamic interactions with low molecular weight heparin (LMWH). However, data are limited, and patients in clinical trials receiving LMWH were taken off the drug at least 8 hours prior to PTCA and administration of bivalirudin.

MANAGEMENT: Until further data are available, coadministration of bivalirudin and all anticoagulants should be undertaken with caution and only after thorough assessment of risks and benefits. Close clinical and laboratory observation for bleeding complications is recommended.

Bivalirudin Intravenous

Generic Name: bivalirudin

Brand name: Angiomax

Synonyms: Bivalirudin

What is Bivalirudin Intravenous?

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?