Bivalirudin Intravenous and Heparin and Sodium Chloride
Determining the interaction of Bivalirudin Intravenous and Heparin and Sodium Chloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using heparin together with bivalirudin. This can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: The concomitant administration of bivalirudin and other anticoagulants may increase the risk of bleeding complications due to additive or synergistic effects on the clotting cascade. In clinical trials, the use of bivalirudin with heparin or warfarin in patients undergoing PTCA was associated with increased risks of major bleeding events. According to the manufacturer, results from drug interaction studies do not suggest pharmacodynamic interactions with low molecular weight heparin (LMWH). However, data are limited, and patients in clinical trials receiving LMWH were taken off the drug at least 8 hours prior to PTCA and administration of bivalirudin.
MANAGEMENT: Until further data are available, coadministration of bivalirudin and all anticoagulants should be undertaken with caution and only after thorough assessment of risks and benefits. Close clinical and laboratory observation for bleeding complications is recommended.
- "Product Information. Angiomax (bivalirudin)" The Medicines Compny, Cambridge, MA.
Generic Name: bivalirudin
Brand name: Angiomax
Synonyms: Bivalirudin
Generic Name: heparin
Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush
Synonyms: Heparin Injection, Heparin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Bivalirudin Intravenous-Heparin flush
- Bivalirudin Intravenous-Heparin Intravenous, Subcutaneous
- Bivalirudin Intravenous-Heparin Lock flush
- Bivalirudin Intravenous-Heparin Lock Flush Solution
- Bivalirudin Intravenous-Heparin Sodium
- Bivalirudin Intravenous-Heparin, Concentrate
- Heparin and Sodium Chloride-Bivigam
- Heparin and Sodium Chloride-Black Cohosh
- Heparin and Sodium Chloride-Black Draught
- Heparin and Sodium Chloride-Blenoxane
- Heparin and Sodium Chloride-Bleo 15k
- Heparin and Sodium Chloride-Bleomycin