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Bleo 15k and OctreoScan

Determining the interaction of Bleo 15k and OctreoScan and the possibility of their joint administration.

Check result:
Bleo 15k <> OctreoScan
Relevance: 08.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using bleomycin together with indium pentetreotide In-111 may cause indium pentetreotide In-111 to accumulate in the lungs leading to toxicity. This combination may also interfere with the results of tests using indium pentetreotide In-111. Drink plenty of fluids prior to receiving indium pentetreotide In-111 to help protect the lungs and other target organs (e.G., thyroid, kidneys, bladder). You should continue extra fluids and void frequently for one day after the indium pentetreotide In-111 test. You may also be instructed to take a mild laxative (e.G., bisacodyl or lactulose) before and after administration of indium pentetreotide In-111. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Indium In-111 pentetreotide may accumulate in the lungs when given concomitantly with bleomycin.

MANAGEMENT: Clinicians should be aware of possible diagnostic interference in patients who are undergoing bleomycin treatment. To help reduce the radiation dose to the lungs and other target organs (e.g., thyroid, kidneys, bladder), patients should be well hydrated prior to the administration of indium In-111 pentetreotide. They should increase fluid intake and void frequently for one day after the scintigraphy. In addition, it is recommended that patients be given a mild laxative (e.g., bisacodyl or lactulose) before and after administration of indium In-111 pentetreotide.

References
  • "Product Information. Octreoscan (indium pentetreotide In-111)." Mallinckrodt Medical Inc, St. Louis, MO.
Bleo 15k

Generic Name: bleomycin

Brand name: Bleo 15k, Blenoxane

Synonyms: n.a.

OctreoScan

Generic Name: indium pentetreotide in-111

Brand name: OctreoScan

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction