Bleomycin and Brentuximab vedotin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using bleomycin together with brentuximab vedotin is not recommended. Bleomycin alone can cause injury to the lungs in approximately 10% of patients, and combining it with brentuximab vedotin may increase that risk. Contact your doctor immediately if you develop coughing, difficulty breathing, shortness of breath, or chest pain during treatment with bleomycin. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration of brentuximab with bleomycin may increase the risk of pulmonary toxicity. The mechanism has not been described. In a clinical trial that involved use of the two agents as part of a combination regimen, the rate of noninfectious pulmonary toxicity was higher than the historical incidence reported with ABVD (adriamycin, bleomycin, vinblastine, dacarbazine). Patients typically reported cough and dyspnea. Interstitial infiltration and/or inflammation were observed on radiographs and computed tomographic imaging of the chest. Most patients responded to corticosteroids.

MANAGEMENT: Concomitant use of brentuximab and bleomycin is considered contraindicated.

Bleomycin

Generic Name: bleomycin

Brand name: Bleo 15k, Blenoxane

Synonyms: n.a.

What is Bleomycin?

Brentuximab vedotin

Generic Name: brentuximab

Brand name: Adcetris

Synonyms: Brentuximab Vedotin

What is Brentuximab vedotin?