Blinatumomab Intravenous and Lazanda

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Blinatumomab may increase the blood levels and effects of fentaNYL. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with blinatumomab may increase the plasma concentrations of drugs that are substrates of CYP450 isoenzymes. Initiation of blinatumomab treatment causes transient release of cytokines that may suppress CYP450 enzymes, although the potential for interaction has not been studied. Presumably, the highest drug-drug interaction risk would be during the first 9 days of the first cycle and the first 2 days of the second cycle.

MANAGEMENT: Caution is advised when blinatumomab is prescribed to patients receiving drugs that are metabolized by CYP450 isoenzymes, particularly those with a narrow therapeutic index such as carbamazepine, colchicine, cyclosporine, disopyramide, phenytoin, quinidine, theophylline, warfarin, macrolide immunosuppressants, vinca alkaloids, and some narcotic analgesics. Clinical and laboratory monitoring are recommended following the initiation of blinatumomab, and the individual dosage of the concomitant agents adjusted as needed.

Blinatumomab Intravenous

Generic Name: blinatumomab

Brand name: Blincyto

Synonyms: Blinatumomab

What is Blinatumomab Intravenous?

Lazanda

Generic Name: fentanyl

Brand name: Lazanda, Abstral, Fentora, Subsys, Actiq, Duragesic, Ionsys, Onsolis, Sublimaze

Synonyms: Lazanda Nasal Spray

What is Lazanda?