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Boceprevir and Isentress HD

Determining the interaction of Boceprevir and Isentress HD and the possibility of their joint administration.

Check result:

Boceprevir <> Isentress HD

Relevance: 02.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of boceprevir and raltegravir may have modest effects on the pharmacokinetics of both drugs. The mechanism of interaction has not been established. When boceprevir 800 mg every 8 hours and raltegravir 400 mg every 12 hours were given together for 6 days, mean boceprevir peak plasma concentration (Cmax) and systemic exposure (AUC) were not significantly altered, but trough plasma concentration (Cmin) decreased by 26%. Likewise, boceprevir 800 mg three times a day for 10 days reduced the Cmin of a single 400 mg dose of raltegravir by 25%. These changes are not considered clinically significant. No dosage adjustment is required for boceprevir or raltegravir.

References

"Product Information. Isentress (raltegravir)." Merck & Company Inc, West Point, PA.
"Product Information. Victrelis (boceprevir)." Schering-Plough Corporation, Kenilworth, NJ.

Boceprevir

Generic Name: boceprevir

Brand name: Victrelis

Synonyms: Boceprevir (Oral)

What is Boceprevir?

Isentress HD

Generic Name: raltegravir

Brand name: Isentress, Isentress HD

Synonyms: Isentress HD (Oral)

What is Isentress HD?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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