Boceprevir and Lanoxin Pediatric Intravenous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Boceprevir may increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with the hepatitis C virus (HCV) NS3/4A protease inhibitors, boceprevir and telaprevir, may increase serum digoxin concentrations and the risk of digoxin toxicity. The proposed mechanism is reduced clearance of digoxin due to inhibition of P-glycoprotein-mediated renal tubular secretion. In 20 study subjects, administration of a single 2 mg dose of digoxin during treatment with telaprevir 750 mg every 8 hours for 11 days increased the digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) by an average of 50% and 85%, respectively, compared to administration alone. No data are available for boceprevir; however, a similar interaction is expected.

MANAGEMENT: Caution is advised if digoxin must be used in combination with boceprevir or telaprevir. Pharmacologic response and serum digoxin levels should be monitored more closely whenever the HCV NS3/4A protease inhibitor is added to or withdrawn from therapy, and the digoxin dosage adjusted as necessary. Patients should be advised to notify their physician if they experience potential signs and symptoms of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

Boceprevir

Generic Name: boceprevir

Brand name: Victrelis

Synonyms: Boceprevir (Oral)

What is Boceprevir?

Lanoxin Pediatric Intravenous

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

What is Lanoxin Pediatric Intravenous?