Bosentan Tablets for Oral Suspension and Kaletra Oral Solution

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using bosentan together with ritonavir. Combining these medications may significantly increase the blood levels of bosentan, potentially increasing the risk of side effects. You may need a dose adjustment if you have been receiving bosentan and are starting treatment with ritonavir, or vice versa. In addition, you may need more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with the pharmacokinetic boosters cobicistat and ritonavir may significantly increase the plasma concentrations of bosentan, particularly during the first few days of combined use. The proposed mechanism is inhibition of the OATP-mediated uptake of bosentan into hepatocytes. In healthy volunteers, coadministration of bosentan (125 mg twice daily) and lopinavir-ritonavir (400-100 mg twice daily) increased the trough concentrations of bosentan on Days 4 and 10 by approximately 48-fold and 5-fold, respectively, compared to those measured after administration of bosentan alone. Bosentan had no significant effect on the pharmacokinetics of lopinavir-ritonavir. In contrast, bosentan may decrease the plasma concentration of cobicistat via induction of CYP450 3A4, which may result in the loss of therapeutic effects and development of resistance.

MANAGEMENT: The dosage of bosentan should be adjusted when used in combination with cobicistat or ritonavir. In patients who have been receiving cobicistat or ritonavir for at least 10 days when bosentan is prescribed, the latter should be initiated at 62.5 mg once daily or every other day depending on individual tolerability. Conversely, in patients who have been receiving bosentan when cobicistat or ritonavir is prescribed, the manufacturers recommend that use of bosentan be discontinued for at least 36 hours prior to initiating the pharmacokinetic booster. After at least 10 days following the initiation of cobicistat or ritonavir, bosentan may be resumed at 62.5 mg once daily or every other day based upon individual tolerability. There is limited experience with abrupt discontinuation of bosentan. Although no evidence for acute rebound has been observed, gradual dose reduction (62.5 mg twice daily for 3 to 7 days) should be considered to minimize the potential for clinical deterioration.

Bosentan Tablets for Oral Suspension

Generic Name: bosentan

Brand name: Tracleer

Synonyms: Bosentan

What is Bosentan Tablets for Oral Suspension?

Kaletra Oral Solution

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: Kaletra

What is Kaletra Oral Solution?