Bosentan Tablets for Oral Suspension and Testosterone Intramuscular
Determining the interaction of Bosentan Tablets for Oral Suspension and Testosterone Intramuscular and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Bosentan may reduce the blood levels and effects of testosterone. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with bosentan may decrease the plasma concentrations of drugs that are substrates of the CYP450 2C9 and/or 3A4 isoenzymes. The mechanism is accelerated clearance due to induction of those isoenzymes by bosentan.
MANAGEMENT: When drugs that are known substrates of CYP450 2C9 and/or 3A4 are coadministered with bosentan, the possibility of a diminished therapeutic response to those drugs should be considered. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs, particularly those with a narrow therapeutic range, whenever bosentan is added to or withdrawn from therapy.
- "Product Information. Tracleer (bosentan)." Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
Generic Name: bosentan
Brand name: Tracleer
Synonyms: Bosentan
Generic Name: testosterone
Brand name: Aveed, Delatestryl, Depo-Testosterone, Testosterone Cypionate, Testosterone Enanthate, Testosterone undecanoate, Xyosted, Androderm, AndroGel Packets, AndroGel Pump 125 g/actuation, FIRST-Testosterone, Fortesta, Testim, Vogelxo, Androgel, Axiron, Natesto, Striant
Synonyms: Testosterone Injection, Testosterone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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