Bosulif and Neut

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Bosutinib and sodium bicarbonate should not be taken orally at the same time. Products that can decrease acid levels in the stomach may interfere with the absorption of bosutinib and reduce its effectiveness. You should take sodium bicarbonate at least 2 hours before or 2 hours after the dose of bosutinib. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Concurrent administration of agents that increase gastric pH such as H2-receptor antagonists or antacids may decrease the oral bioavailability of bosutinib and reduce its concentrations in plasma. The solubility of bosutinib decreases rapidly when the pH is above 5, resulting in reduced absorption. In 24 healthy volunteers, administration of a single 400 mg oral dose of bosutinib in combination with multiple oral doses of the proton pump inhibitor lansoprazole (60 mg) under fasting conditions resulted in a 46% decrease in bosutinib peak plasma concentration (Cmax) and 26% decrease in systemic exposure (AUC) compared to administration of bosutinib alone. The interaction has not been studied with H2-receptor antagonists or antacids.

MANAGEMENT: To minimize the potential for interaction, H2-receptor antagonists or antacids should be administered at least 2 hours before or 2 hours after the bosutinib dose.

Bosulif

Generic Name: bosutinib

Brand name: Bosulif

Synonyms: n.a.

What is Bosulif?

Neut

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Neut Injection

What is Neut?