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Bosutinib and Equate Dual Action Complete

Determining the interaction of Bosutinib and Equate Dual Action Complete and the possibility of their joint administration.

Check result:

Bosutinib <> Equate Dual Action Complete

Relevance: 06.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Bosutinib and famotidine should not be taken orally at the same time. Products that can decrease acid levels in the stomach may interfere with the absorption of bosutinib and reduce its effectiveness. You should take famotidine at least 2 hours before or 2 hours after the dose of bosutinib. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Concurrent administration of agents that increase gastric pH such as H2-receptor antagonists or antacids may decrease the oral bioavailability of bosutinib and reduce its concentrations in plasma. The solubility of bosutinib decreases rapidly when the pH is above 5, resulting in reduced absorption. In 24 healthy volunteers, administration of a single 400 mg oral dose of bosutinib in combination with multiple oral doses of the proton pump inhibitor lansoprazole (60 mg) under fasting conditions resulted in a 46% decrease in bosutinib peak plasma concentration (Cmax) and 26% decrease in systemic exposure (AUC) compared to administration of bosutinib alone. The interaction has not been studied with H2-receptor antagonists or antacids.

MANAGEMENT: To minimize the potential for interaction, H2-receptor antagonists or antacids should be administered at least 2 hours before or 2 hours after the bosutinib dose.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Bosulif (bosutinib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

Bosutinib

Generic Name: bosutinib

Brand name: Bosulif

Synonyms: n.a.

What is Bosutinib?

Equate Dual Action Complete

Generic Name: calcium carbonate / famotidine / magnesium hydroxide

Brand name: Dual Action Complete, Duo Fusion, Pepcid Complete

Synonyms: Dual Action Complete

What is Equate Dual Action Complete?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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