Bosutinib and Zegerid OTC

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using bosutinib together with omeprazole. By decreasing acid levels in the stomach for a prolonged period, omeprazole can interfere with the absorption of bosutinib and reduce its effectiveness. Combining these medications is generally not recommended. Your doctor may be able to prescribe alternatives that do not interact, or interact to a lesser extent. For indigestion or heartburn, you may also consider using an antacid up to two hours before or two hours after the dose of bosutinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with proton pump inhibitors may decrease the oral bioavailability of bosutinib and reduce its concentrations in plasma. The solubility of bosutinib decreases rapidly when the pH is above 5, resulting in reduced absorption. In 24 healthy volunteers, administration of a single 400 mg oral dose of bosutinib in combination with multiple oral doses of lansoprazole 60 mg under fasting conditions resulted in a 46% decrease in bosutinib peak plasma concentration (Cmax) and 26% decrease in systemic exposure (AUC) compared to administration of bosutinib alone. Since proton pump inhibitors affect pH of the upper gastrointestinal tract for an extended period, separation of doses may not eliminate the interaction.

MANAGEMENT: The concomitant use of bosutinib with proton pump inhibitors should generally be avoided. If acid-suppression therapy is required during bosutinib treatment, an H2-receptor antagonist (e.g., cimetidine, famotidine, ranitidine) or antacid may be taken up to 2 hours before or 2 hours after the bosutinib dose.

Bosutinib

Generic Name: bosutinib

Brand name: Bosulif

Synonyms: n.a.

What is Bosutinib?

Zegerid OTC

Generic Name: omeprazole / sodium bicarbonate

Brand name: Zegerid, Zegerid OTC

Synonyms: n.a.

What is Zegerid OTC?