Brentuximab vedotin and Istradefylline

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with inhibitors of P-glycoprotein (P-gp) may increase the plasma concentrations of monomethyl auristatin E (MMAE), the microtubule-disrupting component of brentuximab vedotin. In vitro, MMAE was found to be a substrate of the P-gp efflux transporter. MANAGEMENT: Caution is advised when brentuximab is used with P-gp inhibitors. Close monitoring for adverse effects including neutropenia, infection, peripheral neuropathy, and hepatotoxicity is recommended. References "Product Information. Adcetris (brentuximab vedotin)." Seattle Genetics Inc, Bothell, WA.

MONITOR: Coadministration with inhibitors of P-glycoprotein (P-gp) may increase the plasma concentrations of monomethyl auristatin E (MMAE), the microtubule-disrupting component of brentuximab vedotin. In vitro, MMAE was found to be a substrate of the P-gp efflux transporter.

MANAGEMENT: Caution is advised when brentuximab is used with P-gp inhibitors. Close monitoring for adverse effects including neutropenia, infection, peripheral neuropathy, and hepatotoxicity is recommended.

Brentuximab vedotin

Generic Name: brentuximab

Brand name: Adcetris

Synonyms: Brentuximab Vedotin

What is Brentuximab vedotin?

Istradefylline

Generic Name: istradefylline

Brand name: Nourianz

Synonyms: n.a.

What is Istradefylline?