Brexpiprazole and Tegretol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may reduce the blood levels and effects of brexpiprazole. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of brexpiprazole, which is partially metabolized by this isoenzyme. According to product labeling, administration of brexpiprazole with a potent 3A4 inducer (rifampin) resulted in an approximately 75% decrease in AUC.

MANAGEMENT: During concomitant use with a potent 3A4 inducer, the usual dose of brexpiprazole should be doubled over one to two weeks. When the inducer is discontinued, the brexpiprazole dose should be decreased to its original level over one to two weeks. It is advisable to monitor patients for clinical response.

Brexpiprazole

Generic Name: brexpiprazole

Brand name: Rexulti

Synonyms: n.a.

What is Brexpiprazole?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?