Bridion and Fareston

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Toremifene may interfere with the effects of sugammadex. Reversal of neuromuscular blockade may be delayed if toremifene was taken the day of surgery. The possibility of recurrence of neuromuscular blockade should also be considered, and ventilatory support should be provided as necessary.

MONITOR: Based on studies that demonstrate a relatively high binding affinity of toremifene for sugammadex, theoretical concerns exist that toremifene may displace rocuronium or vecuronium from their complex with sugammadex. This may result in a delayed recovery of the T4/T1 ratio to 0.9 and recurrence of neuromuscular blockade if toremifene is taken on the day of surgery.

MANAGEMENT: Clinicians should be aware that toremifene may delay the reversal of neuromuscular blockade in patients receiving sugammadex. Patients should be closely monitored for signs of recurrence of neuromuscular blockade, and appropriate steps taken to provide adequate ventilation as necessary.

Bridion

Generic Name: sugammadex

Brand name: Bridion

Synonyms: n.a.

What is Bridion?

Fareston

Generic Name: toremifene

Brand name: Fareston

Synonyms: n.a.

What is Fareston?