Brigatinib and Phenytoin Infatabs
Determining the interaction of Brigatinib and Phenytoin Infatabs and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin may significantly reduce the blood levels of brigatinib, which may make the medication less effective or ineffective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of brigatinib, which is partially metabolized by the isoenzyme. When a single 180 mg dose of brigatinib was administered with the potent CYP450 3A4 inducer rifampin (600 mg once daily), brigatinib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 60% and 80%, respectively, compared to brigatinib administered alone.
MANAGEMENT: Concomitant use of brigatinib with potent CYP450 3A4 inducers should generally be avoided.
- "Product Information. Alunbrig (brigatinib)." Ariad Pharmaceuticals Inc, Cambridge, MA.
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Brigatinib-Phenytoin injection
- Brigatinib-Phenytoin Intravenous
- Brigatinib-Phenytoin Oral Suspension
- Brigatinib-Phenytoin Sodium
- Brigatinib-Phenytoin Sodium, Prompt injection
- Brigatinib-Phenytoin Suspension
- Phenytoin Infatabs-Brilinta
- Phenytoin Infatabs-Brilinta Tablets
- Phenytoin Infatabs-Brimonidine
- Phenytoin Infatabs-Brimonidine and brinzolamide ophthalmic
- Phenytoin Infatabs-Brimonidine and Timolol
- Phenytoin Infatabs-Brimonidine and timolol ophthalmic