Brigatinib and Simvastatin Oral Suspension
Determining the interaction of Brigatinib and Simvastatin Oral Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Brigatinib may reduce the blood levels and effects of simvastatin. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with brigatinib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. Brigatinib has been shown in vitro to induce CYP450 3A4 at clinically relevant plasma concentrations.
MANAGEMENT: Caution is advised when brigatinib is used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever brigatinib is added to or withdrawn from therapy.
- "Product Information. Alunbrig (brigatinib)." Ariad Pharmaceuticals Inc, Cambridge, MA.
Generic Name: simvastatin
Brand name: Zocor, Flolipid
Synonyms: Simvastatin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Brigatinib-Simvastatin orally disintegrating tablet
- Brigatinib-Simvastatin Tablets
- Brigatinib-Sinarest
- Brigatinib-Sinarest Nasal
- Brigatinib-Sinarest Sinus
- Brigatinib-Sine-Off Maximum Strength
- Simvastatin Oral Suspension-Brilinta
- Simvastatin Oral Suspension-Brilinta Tablets
- Simvastatin Oral Suspension-Brimonidine
- Simvastatin Oral Suspension-Brimonidine and brinzolamide ophthalmic
- Simvastatin Oral Suspension-Brimonidine and Timolol
- Simvastatin Oral Suspension-Brimonidine and timolol ophthalmic