Brimonidine and brinzolamide ophthalmic and Larotrectinib Sulfate

• Generic Name: brimonidine / brinzolamide ophthalmic
• Dosage Forms: n.a.
• Other Brand Names: Simbrinza

Brimonidine and brinzolamide ophthalmic reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Brimonidine and brinzolamide ophthalmic (for the eyes) is a combination medicine used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye).

Brimonidine and brinzolamide ophthalmic may also be used for purposes not listed in this medication guide.

• Generic Name: larotrectinib
• Dosage Forms: n.a.
• Other Brand Names: Vitrakvi

Treatment of solid tumors harboring an NTRK fusion (without a known acquired mutation for resistance) in patients who have metastatic disease or may experience severe morbidity following surgical resection and whose disease progressed following prior therapy or those who are not candidates for other treatment options (designated an orphan drug by FDA for these cancers).

Accelerated approval based on overall response rate and duration of response. Continued approval may be contingent on verification and description of clinical benefit in confirmatory studies.

Confirmation of the presence of NTRK fusion is necessary prior to initiation of therapy. In clinical studies, NTRK fusion status of tumor specimens was determined by fluorescence in situ hybridization (FISH), reverse transcription-polymerase chain reaction (RT-PCR), or next-generation sequencing (NGS).