Brimonidine topical and Furomide M.D.
Determining the interaction of Brimonidine topical and Furomide M.D. and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:After using brimonidine topical, some of the medication may be absorbed into the bloodstream and occasionally produce cardiovascular side effects such as decreases in blood pressure and heart rate. Combining it with furosemide or other medications that can also have these effects may increase the risk. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart beat. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Topically administered alpha-2 adrenergic receptor agonists such as apraclonidine and brimonidine are systemically absorbed, with the potential for producing rare but clinically significant systemic effects such as hypotension and bradycardia. The possibility for an additive or potentiating effect on blood pressure and heart rate should be considered when used with other medications that affect these parameters, such as ophthalmic and systemic beta blockers, vasodilators, cardiac glycosides, and antihypertensive agents.
MANAGEMENT: Blood pressure and pulse rate should be monitored regularly when topical alpha-2 adrenergic receptor agonists are prescribed in combination with cardiovascular drugs. Patients should be advised to notify their physician if they experience slow pulse, irregular heartbeat, dizziness, lightheadedness, or syncope.
- King MH, Richards DW "Near syncope and chest tightness after administration of apraclonidine before argon laser iridotomy." Am J Ophthalmol 110 (1990): 308-9
- Nordlund JR, Pasquale LR, Robin AL, Rudikoff MT, Ordman J, Chen KS, Walt J "The cardiovascular, pulmonary, and ocular hypotensive effects of 0.2% brimonidine." Arch Ophthalmol 113 (1995): 77-83
- Pekdemir M, Yanturali S, Karakus G "More than just an ocular solution." Emerg Med J 22 (2005): 753-4
- "Product Information. Mirvaso (brimonidine topical)." Galderma Laboratories Inc, Cranbury, NJ.
- "Product Information. Iopidine (apraclonidine)." Alcon Laboratories Inc, Fort Worth, TX.
- "Product Information. Alphagan (brimonidine ophthalmic)." Allergan Inc, Irvine, CA.
- Walters TR "Development and use of brimonidine in treating acute and chronic elevations of intraocular pressure: a review of safety, efficacy, dose response, and dosing studies." Surv Ophthalmol 41 ( Suppl (1996): s19-26
Generic Name: brimonidine topical
Brand name: Mirvaso, Mirvaso Pump
Synonyms: Brimonidine (Topical)
Generic Name: furosemide
Brand name: Lasix, Diaqua-2, Lo-Aqua
Synonyms: Furosemide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Brimonidine topical-Furosemide
- Brimonidine topical-Furosemide Injection
- Brimonidine topical-Furosemide Oral Solution
- Brimonidine topical-Furosemide Tablets
- Brimonidine topical-FusePaq Fanatrex
- Brimonidine topical-FusePaq Synapryn
- Furomide M.D.-Brimonidine Topical application
- Furomide M.D.-Brintellix
- Furomide M.D.-Brinzolamide
- Furomide M.D.-Brinzolamide and Brimonidine
- Furomide M.D.-Brinzolamide ophthalmic
- Furomide M.D.-Brioschi