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Brisdelle and Cyproheptadine Solution

Determining the interaction of Brisdelle and Cyproheptadine Solution and the possibility of their joint administration.

Check result:

Brisdelle <> Cyproheptadine Solution

Relevance: 28.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Cyproheptadine may reverse or reduce the effects of PARoxetine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Serotonin antagonists such as cyproheptadine and methysergide may diminish the pharmacologic effects of selective serotonin reuptake inhibitors (SSRIs) and other highly serotonergic agents (e.g., 5-hydroxytryptophan; buspirone; mirtazapine; nefazodone; sibutramine; St. John's wort; trazodone; SNRIs such as duloxetine, desvenlafaxine, milnacipran, and venlafaxine). This pharmacodynamic interaction is sometimes exploited in the use of cyproheptadine and methysergide for the treatment of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Theoretically, serotonergic agents may also antagonize the pharmacologic effects of cyproheptadine and methysergide, although this effect has not been reported.

MANAGEMENT: Patients should be monitored for potentially diminished therapeutic response to serotonergic agents during coadministration with cyproheptadine or methysergide, and dosages adjusted as necessary.

References

Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13
Lane R, Baldwin D "Selective serotonin reuptake inhibitor--induced serotonin syndrome: review." J Clin Psychopharmacol 17 (1997): 208-21
Goldbloom DS, Kennedy SH "Adverse interaction of fluoxetine and cyproheptadine in two patients with bulimia nervosa." J Clin Psychiatry 52 (1991): 261-2
Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763
Katz RJ, Rosenthal M "Adverse interaction of cyproheptadine with serotonergic antidepressants." J Clin Psychiatry 55 (1994): 314-5
Klepser T, Nisly N "5-Hydroxytryptophan (5-HTP) for treatment of depression." Alternative Medicine Alert 3 (2000): 121-4
Feder R "Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients." J Clin Psychiatry 52 (1991): 163-4
Christensen RC "Adverse interaction of paroxetine and cyproheptadine." J Clin Psychiatry 56 (1995): 433-4
Nierenberg DW, Semprebon M "The central nervous system serotonin syndrome." Clin Pharmacol Ther 53 (1993): 84-8
Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6

Brisdelle

Generic Name: paroxetine

Brand name: Brisdelle, Paxil, Paxil CR, Pexeva

Synonyms: n.a.

What is Brisdelle?

Cyproheptadine Solution

Generic Name: cyproheptadine

Brand name: Periactin

Synonyms: Cyproheptadine

What is Cyproheptadine Solution?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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