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Brisdelle and Gilteritinib Fumarate

Determining the interaction of Brisdelle and Gilteritinib Fumarate and the possibility of their joint administration.

Check result:
Brisdelle <> Gilteritinib Fumarate
Relevance: 28.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Gilteritinib may reduce the effectiveness of PARoxetine in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with gilteritinib may reduce the pharmacologic effects of drugs that target the 5-HT2B receptor or the sigma nonspecific receptor, such as selective serotonin reuptake inhibitors. In vitro studies indicate that gilteritinib inhibits human 5-HT2B and sigma nonspecific receptors; however, clinical data are lacking.

MANAGEMENT: Concomitant use of gilteritinib with drugs that target the 5-HT2B receptor or the sigma nonspecific receptor should generally be avoided unless their use is considered essential to the care of the patient.

References
  • "Product Information. Xospata (gilteritinib)." Astellas Pharma US, Inc, Deerfield, IL.
Brisdelle

Generic Name: paroxetine

Brand name: Brisdelle, Paxil, Paxil CR, Pexeva

Synonyms: n.a.

Gilteritinib Fumarate

Generic Name: gilteritinib

Brand name: Xospata

Synonyms: Gilteritinib

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction