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Briviact and Zovia 1/50e

Determining the interaction of Briviact and Zovia 1/50e and the possibility of their joint administration.

Check result:

Briviact <> Zovia 1/50e

Relevance: 24.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with brivaracetam at higher than recommended dosages may decrease the plasma concentrations of contraceptive hormones. The mechanism may involve weak induction of CYP450 3A4 metabolism by brivaracetam. In 24 healthy premenopausal women given an oral contraceptive containing ethinyl estradiol 30 mcg and levonorgestrel 150 mcg in combination with brivaracetam 200 mg twice daily (twice the recommended maximum daily dosage), a reduction in estrogen and progestin systemic exposure (AUC) of 27% and 23%, respectively, was observed without impact on suppression of ovulation. There was generally no difference in levels of the endogenous hormones estradiol, progesterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), and sex hormone binding globulin (SHBG) during the cycle with brivaracetam compared to the control cycle, and the combination was well tolerated. When the oral contraceptive was administered with brivaracetam 50 mg twice daily, no significant effects were observed on the pharmacokinetics of either ethinyl estradiol or levonorgestrel. Steady-state brivaracetam trough levels were also not affected by the oral contraceptive. Based on existing data, the interaction is not expected to be clinically relevant, and no particular precaution appears necessary when brivaracetam is used with oral contraceptives.

References

"Product Information. Briviact (brivaracetam)." UCB Pharma Inc, Smyrna, GA.
Stockis A, Watanabe S, Fauchoux N "Interaction between brivaracetam (100 mg/day) and a combination oral contraceptive: a randomized, double-blind, placebo-controlled study." Epilepsia 55 (2014): e27-31
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Stockis A, Rolan P "Effect of brivaracetam (400 mg/day) on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive in healthy women." J Clin Pharmacol 53 (2013): 1313-21

Briviact

Generic Name: brivaracetam

Brand name: Briviact

Synonyms: n.a.

What is Briviact?

Zovia 1/50e

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/50, Zovia 1/50E

What is Zovia 1/50e?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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