Briviact (Brivaracetam Injection) and Sustiva (Efavirenz Capsules)
Determining the interaction of Briviact (Brivaracetam Injection) and Sustiva (Efavirenz Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 2C19 may increase the plasma concentrations of brivaracetam, which is partially metabolized by the isoenzyme. Blood level of brivaracetam is increased by 22% or 42%, respectively, in human subjects possessing genetic variations in CYP450 2C19 with one or both mutated alleles, while production of the hydroxy metabolite is decreased by 2-fold or 10-fold, respectively. The risk of a clinically relevant CYP450 2C19-mediated interaction is considered to be low according to the manufacturer.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Briviact (brivaracetam)." UCB Pharma Inc, Smyrna, GA.
Generic Name: brivaracetam
Brand name: Briviact
Synonyms: Briviact
Generic Name: efavirenz
Brand name: Sustiva
Synonyms: Sustiva
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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