Briviact Intravenous and Microgestin 24 Fe

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with brivaracetam at higher than recommended dosages may decrease the plasma concentrations of contraceptive hormones. The mechanism may involve weak induction of CYP450 3A4 metabolism by brivaracetam. In 24 healthy premenopausal women given an oral contraceptive containing ethinyl estradiol 30 mcg and levonorgestrel 150 mcg in combination with brivaracetam 200 mg twice daily (twice the recommended maximum daily dosage), a reduction in estrogen and progestin systemic exposure (AUC) of 27% and 23%, respectively, was observed without impact on suppression of ovulation. There was generally no difference in levels of the endogenous hormones estradiol, progesterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), and sex hormone binding globulin (SHBG) during the cycle with brivaracetam compared to the control cycle, and the combination was well tolerated. When the oral contraceptive was administered with brivaracetam 50 mg twice daily, no significant effects were observed on the pharmacokinetics of either ethinyl estradiol or levonorgestrel. Steady-state brivaracetam trough levels were also not affected by the oral contraceptive. Based on existing data, the interaction is not expected to be clinically relevant, and no particular precaution appears necessary when brivaracetam is used with oral contraceptives.

Briviact Intravenous

Generic Name: brivaracetam

Brand name: Briviact

Synonyms: Briviact

What is Briviact Intravenous?

Microgestin 24 Fe

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: Microgestin 24 FE (birth control)

What is Microgestin 24 Fe?