Brodspec and Potassium Citrate and Citric Acid Solution
Determining the interaction of Brodspec and Potassium Citrate and Citric Acid Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using potassium citrate together with tetracycline may decrease the effects of tetracycline. Administration of potassium citrate and tetracycline should be separated by three to four hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve increased renal elimination of tetracyclines when the urine becomes alkalinized. Information is available for doxycycline, tetracycline, and sodium bicarbonate only.
MANAGEMENT: If these drugs must be used together, an alternating dosing schedule is recommended (three to four hours apart).
- Elliott GR "Sodium bicarbonate and oral tetracycline." Clin Pharmacol Ther 13 (1972): 459
- Jaffe JM, Colaizzi JI, Poust RI, McDonald RH Jr "Effect of altered urinary pH on tetracycline and doxycycline excretion in humans." J Pharmacokinet Biopharm 1 (1973): 267-82
- Jaffe JM, Poust RI, Feld SL, Colaizzi JL "Influence of repetitive dosing and altered urinary pH on doxycycline excretion in humans." J Pharm Sci 63 (1974): 1256-60
Generic Name: tetracycline
Brand name: Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap, Tetracon, Robitet 500, Emtet-500
Synonyms: n.a.
Generic Name: citric acid / potassium citrate
Brand name: Cytra-K, Poly-Citra K Crystals, Polycitra-K, Virtrate-K
Synonyms: Citric acid and potassium citrate, Potassium Citrate-Citric Acid Crystals
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Brodspec-Potassium Citrate-Citric Acid Crystals
- Brodspec-Potassium Citrate-Sodium Citrate-Citric Acid Solution
- Brodspec-Potassium gluconate
- Brodspec-Potassium Gluconate Capsules and Tablets
- Brodspec-Potassium Gluconate Controlled-Release Tablets
- Brodspec-Potassium iodide
- Potassium Citrate and Citric Acid Solution-Brom Mal Phenyl HCl Dex HBr
- Potassium Citrate and Citric Acid Solution-Bromaline
- Potassium Citrate and Citric Acid Solution-Bromaline DM
- Potassium Citrate and Citric Acid Solution-Bromatan Plus
- Potassium Citrate and Citric Acid Solution-Bromatan-DM
- Potassium Citrate and Citric Acid Solution-Bromax Tablets