Bromatan Plus and Gilteritinib Fumarate

• Generic Name: dexchlorpheniramine / dextromethorphan / pseudoephedrine
• Dosage Forms: n.a.
• Other Brand Names: Abatuss DMX, Bromatan Plus, SuTan-DM, Deltuss DMX, Tanafed DMX, Tannate DMP-DEX, C-Phed DPD Tann, Tanafed-DMX, DuraTan Forte, Dur-Tann Forte, TanDur DM, Tannate PD-DM

Dexchlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Bromatan Plus is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, and sinus congestion caused by allergies, the common cold, or the flu.

Bromatan Plus will not treat a cough that is caused by smoking, asthma, or emphysema.

Bromatan Plus may also be used for purposes not listed in this medication guide.

• Generic Name: gilteritinib
• Dosage Forms: n.a.
• Other Brand Names: Xospata

For the treatment of relapsed or refractory AML harboring Flt-3 mutation (designated an orphan drug by FDA for this use).

FDA-approved companion diagnostic test (e.g., LeukoStrat CDx Flt-3 mutation assay) required to confirm presence of Flt-3 mutation prior to initiation of therapy.